Isna is located about 33 miles south of Luxor. The town’s Greek name was Latopolis and here fish (lates) where thought to embody the goddess Neith, who was sacred to the area.  Isna was increasingly important during the 18th dynasty due to Egypt’s developing relationship with the Sudan.  There was a route established between Isna and Derr. Later, the city slowly declined until it received renewed interest during the 26th Dynasty.  Later, under the Greeks and Romans, it became the capital of the Third Nome of Upper Egypt.

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